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hrp0089fc6.6 | Fat, Metabolism and obesity | ESPE2018

MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the Subsequent Hepatic Steatosis and Insulin Resistance

Nourbakhsh Mitra , Yousefi Zeynab , Nikroo Nikta Dadkhah , Malek Mojtaba , Pazouki Abdolreza , Mokhber Somayye

Introduction: Obesity increases the risk of various disorders including diabetes, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disorders. MicroRNAs (miRNA) are single-stranded, non-coding oligonucleotides that regulate gene expression. Sirtuin 1 (SIRT1), a regulatory enzyme in metabolic homeostasis, is regulated by miRNAs. The aim of this study was to evaluate miR-141 in obesity and whether this miRNA can regulate SIRT1 expression.Materia...

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hrp0086p2-p334 | Diabetes P2 | ESPE2016

Minimally Invasive Surgical Interventions in the Treatment of Primary Persistent Hyperinsulinemic Hypoglycemia of Infancy

Soheilipour Fahimeh , Jesmi Fatemeh , Ahmadi Mohammad , Pazouki Abdolreza , Alibeigi Peyman , Abdolhosseini Mohammadreza

Case Report: Hyperinsulinemia, diagnosed by laboratory tests, should be diagnosed and treated as soon as possible to prevent fatal complications such as neurological damage. Patients who are resistant to medical therapy should be treated surgically. Minimally invasive surgery, a newly developed approach, is a good choice among surgical procedures to avoid unnecessary extensive pancreatectomy. Here, a 12-year-old boy is presented with diagnosis of hyperinsulinemic hypoglycemia ...

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ESPE Abstracts

MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the Subsequent Hepatic Steatosis and Insulin Resistance

Minimally Invasive Surgical Interventions in the Treatment of Primary Persistent Hyperinsulinemic Hypoglycemia of Infancy

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